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Sandra Williams

Student,Pawling High School,USA

Title: The Effect of 20- HETE Antagonism on Myocardial Infarction of Metabolic Syndrome Rats


Biography: Sandra Williams


20-hydroxyeicosatetraenoic acid (20-HETE) is an eicosanoid metabolite of that has a wide range of effects on the vascular system such as Collateral cell growth, vascular rebuilding of the heart. Metabolic Syndrome and 20-HETE have been shown to be correlated together.There is a higher concentration of 20-HETE in Metabolic Syndrome patients. With a higher concentration of 20-HETE patients with Metabolic syndrome have symptoms that are more severe. The effect of elevated 20-HETE is negative and can influence the cell growth after a Myocardial Infarction. Myocardial Infarction (MI) is another term for a heart attack. In previous studies, it shows an MI size increases with an elevated level of 20-HETE. During the study, the Metabolic Syndrome rats and control group of rats will be induced with an MI for about 30-minutes. After rats from both groups are given an MI and 20-HETE antagonist named 20-SOLA which counteracts 20-HETE levels will be given. 20-SOLA treatment was given to the rats at 48 hours, 1 week and 8 weeks. The results indicated that the AMPK antibody for both total and phosphorylated showed a significant decrease in 48-hour samples. 20-SOLA was found to create an equilibrium in 20-HETE levels in all tissue samples and significantly more in JCR MI rats. 20-SOLA aided the decrease in ischemia for both rats, but again results indicate a more reliable significance in JCR MI rats. These findings are relevant to the epidemic of cardiovascular diseases plaguing populations globally.